IL-6遺伝子欠損マウス。免疫能低下。加齢に従い軽度肥満。 条件を付加する。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。Nature, 368, 339-342 (1994).<br>研究成果の公表にあたって謝辞の表明を必要とする。 Developed by Manfred Kopf, Max-Planck-Institut fur Immunbiologie in 1994. The mice were backcrossed to C57BL/6 for at least 8 times by Yoichiro Iwakura, The Institute of Medical Science, The University of Tokyo. B6;129S2-Il6<tm1Kopf> B6;129S2-Il6<tm1Kopf> covid19_onset RBRC04918 Necessary documents for ordering:<ol><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol> 1994年 Max-Planck-Institut fur Immunbiologie, Dr. Manfred Kopfらにより開発。D3 ES細胞由来。東大医科研岩倉研でC57BL/6Jに8世代戻し交配 (兄妹交配9代) (BRC寄託時)。129S2/SvPas (D3) <a href='https://brc.riken.jp/mus/pcr04918'>Genotyping protocol -PCR-</a> C（3〜6か月） Yoichiro IWAKURA 岩倉　洋一郎 B6.129S2-Il6<tm1Kopf> 1994年 Max-Planck-Institut fur Immunbiologie, Dr. Manfred Kopfらにより開発。 D3 ES細胞由来。東大医科研岩倉研でC57BL/6Jに8世代戻し交配 (兄妹交配9代) (BRC寄託時)。 129S2/SvPas (D3) C (3-6 months) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nature, 368, 339-342 (1994).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. IL-6 knockout mice. Homozygous mutant mice show decreased immune competence. slight overweight with aging. true herpes simplex virus thymidine kinase promoter (HSV tk promoter), Neomycin resistance gene (E. coli), PolyA signal (SV40), mouse Il6 genomic DNA B6-Il6 KO Immunology and Inflammation Research C57BL/6J (亜系統は不明)